At an up-and-down 3-4, the reigning NFC champion San Francisco 49ers can’t be reliably counted on as a bona fide contender. That makes Brandon Aiyuk’s season-ending knee injury an outright disaster for a Bay Area constellation of football superstars still chasing an elusive Lombardi Trophy.

It was another difficult day on the injury front including the QB3 entering Week 7 and one of last year's top wideouts. We have the latest updates.