And yet Kyle Shanahan treated it like he treats all games: He played not to lose. So the 49ers lost.

At an up-and-down 3-4, the reigning NFC champion San Francisco 49ers can't be reliably counted on as a bona fide contender.

In the first quarter of the rematch of last year's Super Bowl between the Kansas City Chiefs and San Francisco 49ers, former ...

Pearsall's first catch came late in the second quarter and garnered a standing ovation from 49er fans in the stands at Levi's ...

The San Francisco 49ers sustained an ugly defeat against Kansas City Chiefs, maybe providing some upset hope for their old rivals the Dallas Cowboys.

The Kansas City Chiefs beat the San Francisco 49ers, and are now the sole unbeaten team in the NFL. Colin Cowherd discusses their victory and the possibility of a three-peat.

The San Francisco 49ers and fantasy football managers won't have star wide receiver Brandon Aiyuk at their disposal anytime soon following his knee injury.

About 10 minutes before the Chiefs and San Francisco 49ers kicked off in California, a football game played 2,000 miles away ...

San Francisco 49ers WR Deebo Samuel is expected to be traded ahead of the deadline following widespread summer rumors.

Here are some key trends and stats to see before placing any bets on Jordan Mason’s player prop bet markets for Sunday’s game ...

The San Francisco 49ers and Kansas City Chiefs don’t have a primetime slot when they face off Sunday in a Super Bowl rematch.

Jordan Mason lost two short scores to his QB and was shut down by a KC defense allowing the fewest fantasy points to RBs, but ...